Phone: (602) 307-0070

Fax: (602) 307-0080

James Kneller, MD

James Kneller, M.D., Ph.D., FHRS, CCDS

Expertise

Electrophysiology & Cardiovascular Disease

Dr. Kneller earned his medical degree from McGill University, Montreal QC, Canada. In addition he hold a Ph.D. in Pharmacology from McGill University, a M.Sc. in Bioengineering from the University of Pittsburg, PA and a B.Sc. in Mechanical Engineering , Magna Cum Laude with a minor in mathematics from Walla Walla, University, College Place, WA. He has completed a cardiovascular fellowship at New York Presbyterian, Columbia University Medical Center and Clinical Cardiac Electrophysiology Fellowships at the Medical College of Virginia, Richmond, VA and UCLA Cardiac Arrhythmia Center, David Geffen School of Medicine, Ronald Regan UCLA Medical Center, University of California, Los Angeles, CA.

He holds Board Certification in Clinical Cardiac Electrophysiology, Cardiovascular Disease and internal Medicine. Dr. Kneller is a Fellow of the Heart Rhythm Society (FHRS) and a Certified Cardiac Device Specialist (CCDS). Dr. Kneller holds appointments as a Clinical Assistant Professor, Elson S. Floyd College of Medicine, Washington State University and Adjunct Clinical Associate Professor, Pacific Northwest University of Health Sciences, Yakima, WA, Clinical Associate Professor, Internal Medicine (pending) University of Arizona, Tucson, AZ.

Dr. Kneller has conducted research in the area of electrophysiology. He serves on the Editorial Board of EP Digest.

Publications

  1. Rubenstein D, Weston L, Kneller J, Wright C, Hang Y. Safe Extraction of Riata Looped Extruding Filler Cables. J Cardiovasc Electrophysiol. 2013 Aug;24(8):942-6.
  2. Kneller J*, DeLacey W, Wood MA, Ellenbogen KA. Detection of a Riata Lead Fracture by the Medtronic Lead Integrity Algorithm. Europace. 2012 Aug;14(8):1215-6 [*Corresponding Author]
  3. Kneller J, Shivkumar K, Tung R. Assessment of His-Purkinje Reserve: What is the mechanism of block? Heart Rhythm 2012 Mar;9(3):465-6.
  4. M. Reumann, C. Vasquez, S. A. Bernstein, J. Kneller, J. J. Rice, and G. E. Morley. Can current modeling approaches of atrial ablation capture in – vivo and in – vitro experimental observations accurately? IFMBE Proceedings World Congress on Medical Physics and Biomedical Engineering 2009, Munich, Germany
  5. Comtois P, Kneller J, Nattel S. Of circles and spirals: bridging the gap between the leading circle and the spiral wave concepts of cardiac reentry. Europace. 2005;7 Suppl 2:10-20.
  6. Pandit SV, Berenfeld O, Anumonwo J, Zaritski R, Kneller J, Nattel S, Jalife J. Ionic determinants of functional reentry in a 2-D model of human atrial cells during simulated chronic atrial fibrillation. Biophys J. 2005;88:3806-21.
  7. Zou R, Kneller J, Leon JL, Nattel S. Substrate size as a determinant of fibrillatory activity maintenance in a mathematical model of canine atrium. Am J Physiol Heart Circ Physiol. 2005;289:H1002-12.
  8. Kneller J, Kalifa J, Zou R, Zaitsev AV, Warren M, Berenfeld O, Vigmond EJ, Leon LJ, Nattel S, Jalife J. Mechanisms of atrial fibrillation termination by pure sodium channel blockade in an ionically-realistic mathematical model. Circ Res. 2005;96:e35-47.
  9. Vigmond EJ, Tsoi V, Kuo S, Arevalo H, Kneller J, Nattel S, Trayanova N. The effect of vagally induced action potential duration dispersion on atrial arrhythmogenesis. Heart Rhythm. 2004;1:334-44.
  10. Nattel S, Kneller J, Zou R, Leon LJ. Mechanisms of Termination of Atrial Fibrillation by Class I Antiarrhythmic Drugs: Evidence from Clinical, Experimental and Mathematical Modeling Studies. J Cardiovasc Electrophysiol. 2003;14:S133-S139.
  11. Kneller J, Zou R, Vigmond EJ, Wang Z, Leon LJ, Nattel S. Cholinergic atrial fibrillation in a computer model of a 2-dimensional sheet of canine atrial cells with realistic ionic properties. Circ Res. 2002;90:e73-87. (featured on cover of journal)
  12. Kneller J, Ramirez RJ, Chartier D, Courtemanche M, Nattel S. Time-dependent transients in an ionically-based mathematical model of the canine atrial action potential. Am J Physiol Heart Circ Physiol. 2002;282:H1437-51.
  13. Kneller J, Sun H, Leblanc N, Nattel S. Remodeling of Ca(2+)-handling by atrial tachycardia: evidence for a role in loss of rate-adaptation. Cardiovasc Res. 2002;54:416-26.
  14. Zou R, Kneller J, Leon LJ, Nattel S. Development of a computer algorithm for the detection of phase singularities and initial application to analyze simulations of atrial fibrillation. Chaos 2002;12:764-778.
  15. Li D, Zhang L, Kneller J, Nattel S. Potential ionic mechanism for repolarization differences between canine right and left atrium. Circ Res. 2001;88:1168-75.
  16. Feldman MD, Sun B, Koci BJ, Wu CC, Kneller JR, Borovetz HS, Watkins S, Nadeem A, Weiss LE, Reed ML, Smith AJC, Rosenblum WD. Stent-based gene therapy. J Long Term Eff Med Implants. 2000;10(1&2):47-68. Review.
  17. Kneller JR, Wu C, Vorp DA, Reed M, Weiss LE, Borovetz HS, Watkins S, Feldman MD. The use of microfabricated probes to penetrate the internal elastic lamina and intimal hyperplasia. J Cardiovasc Diagn Proced. 1999;16(2):37-50.
  18. Reed ML, Wu C, Kneller JR, Vorp DA, Nadeem A, Weiss LE, Rebello K, Mescher M, Smith AJ, Rosenblum W, Feldman MD. Micromechanical devices for intravascular drug delivery. J Pharm Sci. 1998;87(11):1387-94.

Abstracts

  1. American Heart Association (AHA)
  2. Kneller J, Zou R, Vigmond EJ, Leon J, Nattel S. Termination of atrial fibrillation by class III antiarrhythmic drugs – does disorganization of activity favor atrial fibrillation maintenance? Circulation. 2003;108(17):IV-147.
  3. Kalifa J, Kneller J, Zaitsev AV, Bagwe S, Warren M, Guha PK, Berenfeld O, Leon LJ, Jalife J, Nattel S. Mechanism of atrial fibrillation termination by sodium channel blockers: insights from computational and experimental data. Circulation. 2003;108(17):IV-148.
  4. Zou R, Kneller J, Leon LJ, Nattel S. Mechanisms of AF in substrates of varying size probed with a realistic mathematical model: Moe and Mines revisited. Circulation. 2002;106(19):II-154.
  5. Kneller J, Zou R, Wang Z, Leon J, Nattel S. An ionically based computer model of atrial fibrillation: multiple wavelets versus a focal source with wavelet breakup. Circulation. 2001;104(17):II-4.
    1.08.2020 CURRICULUM VITAE James Kneller M.D., M.Sc., Ph.D., FHRS, CCDS
  6. Kneller J, Leon J, Nattel S. How do class I antiarrhythmic drugs terminate atrial fibrillation? – a quantitative analysis based on a realistic ionic model. Circulation. 2001;104(17):II-5.
  7. Kneller J, Sun H, Leblanc N, Nattel S. Cellular mechanisms of atrial tachycardia-induced action potential remodeling: Evidence for a crucial role of Ca2+-handling abnormalities. Circulation. 2000;102(18):II-192.

Heart Rhythm Society (HRS)

  1. Kneller J, Uy M, Garfinkel A. Structure and Dynamics Interact in a Computational Model of Paroxysmal Atrial Fibrillation. Abstract Number: 3783; Poster Board Number: PO2-89; Poster Session Title/ Number: Poster Session II / PO-02; Poster Session Start/End Time: 5/10/2012, 9:30:00 AM- 12:00:00 PM.
  2. Bernstein S, Kneller J, Vasquez C, Kuznekoff L, Fowler S, Shin W, Holmes D, Chinitz L, Morley GE. Inflammation is Essential for Successful Atrial Fibrillation Ablation. HRS 2010 [AB16-2] Session Info: Pathophysiology of Atrial Fibrillation Ablation: Lessons Learned from Ablation Thursday, May 13, 2010, 1:30 PM-3:00 PM.
  3. Bernstein S, Kneller J, Vasquez C, Kuznekoff L, Fowler S, Shin W, Wong B, Holmes D, Chinitz L, Morley GE. Attenuation of RF ablation Energy Delivery in Tachypaced Atrial Tissue. HRS 2010 [PO4-75] Session Info: Poster Session 4 Friday, May 14, 2010, 9:00 AM-12:00 PM.

American College of Cardiology

  1. Feldman M, Kneller J, Wu C, Watkins S, Weiss L, and Reed ML. Microfabricated device for intravascular delivery. (Oral presentation, 47th ACC Annual Scientific Sessions, Atlanta, GA, USA. March 29-April 1, 1998) J Am Coll Cardiol. 1998;31(2):351A.

International Academy of Cardiology

  1. Kneller JR, Merrill K, Evans T, Larios K, Thorndike J. Permanent His Bundle Pacing (PHBP) With CLS Outperforms Accelerometer-Based Rate-Responsive Pacing. (Poster presentation at International Academy of Cardiology, Annual Scientific Sessions 2017, 22nd World Congress on Heart Disease, Vancouver BC, Canada, July 14-16) Cardiology 2017;137(suppl 1):168.
  2. Kneller J, Bird T, Bird L. Patients Favor Shape of Medtronic ICD, Battery Life Often More Important. (Poster presentation at International Academy of Cardiology, Annual Scientific Sessions 2016, 21st World Congress on Heart Disease, Boston, MA, USA, July 30 – August 1) Cardiology 2016;134(suppl 1):279.

2018 AF Symposium

  1. Kneller J, Discrepancies in reporting of atrial fibrillation (AF) between a Medtronic LINQTM and pacemaker. J Cardiovasc Electrophys, 2018;29(4):AFS-2018-2.

Biophysical Society

  1. Zou R, Kneller J, Leon LJ, Nattel S. Role of substrate size in the mechanisms of atrial fibrillation. Biophys J. 2003;84(2):406A.
  2. Zou R, Kneller J, Leon LJ3, Nattel S. A novel method to detect phase singularity during atrial fibrillation. Biophys J. 2002;82(1):93A.
  3. Kneller JR, Ramirez R, Chartier D, Nattel S, Courtemanche M. Ion concentration drift and action potential transients in canine atrial tissue and ionic models. Biophys J. 2000;78(1): 454A.
  4. New York University (NYU)
  5. Radiofrequency Ablation in Chronically Fibrillating Hearts, Bernstein SA, Kneller J, Vasquez C, Kuznekoff L, Fowler S, Shin W, Holmes D, Chinitz L, and Morley GE (Poster presentation, NYU Department of Medicine Research Day, 2010).
  6. CURRICULUM VITAE James Kneller M.D., M.Sc., Ph.D., FHRS, CCDS
  7. Inflammation Is Essential for Successful Atrial Fibrillation Ablation, Bernstein SA, Kneller J, Vasquez C, Kuznekoff L, Fowler S, Shin W, Holmes D, Chinitz L, and Morley GE (Poster presentation, NYU Department of Medicine Research Day, 2010).

Canadian Society of Clinical Investigation (CSCI)

  1. Kneller J, Zou R, Leon LJ, Nattel S. How do class I antiarrhythmic drugs terminate atrial fibrillation? – a quantitative analysis based on a realistic ionic model. (Young investigator’s Forum, CSCI Annual Meeting, September 2002 Ottawa, Ontario Canada).
  2. Kneller J, Sun H, Leblanc N, Nattel S. Cellular mechanisms of atrial tachycardia-induced action potential remodeling: evidence for a crucial role of Ca2+-handling abnormalities in loss of rate-adaptation. (Young investigator’s Forum, CSCI Annual Meeting, September 2001 Ottawa, Ontario Canada).
  3. Kneller J, Shi H, Derakhchan K, Wang Z, Leon LJ, Nattel S. A quantitative analysis of mechanisms of atrial arrhythmias resulting from vagal tone in a mathematical model of dog atrium. (Young investigator’s Forum, CSCI Annual Meeting, September 21, 2000 Edmonton, Alberta Canada).

Montreal Heart Institute

  1. Zou R, Kneller J, Leon LJ, Nattel S. A novel method to detect phase singularity during atrial fibrillation. (Journée de la Recherche de l’Institut de Cardiologie de Montréal, May 30, 2002, Livre des résumés).
  2. Kneller J, Zou R, Wang Z, Leon J, Nattel S. An ionically-based computer model of atrial fibrillation: multiple wavelets versus a focal source with wavelet breakup. (Journée de la Recherche de l’Institut de Cardiologie de Montréal, June 13, 2001, Livre des résumés).
  3. Kneller J, Sun H, Leblanc N, Nattel S. Cellular mechanisms of atrial tachycardia-induced action potential remodeling: Evidence for a crucial role of Ca2+-handling abnormalities. (Journée de la Recherche de l’Institut de Cardiologie de Montréal, June 8, 2000, Livre des résumés).

Engineering & Mathematics Societies

  1. Zou R, Kneller J, Leon LJ, Nattel S. Spatiotemporal periodicity in a realistic mathematical model of atrial fibrillation. (Poster session, MITACS Annual General Meeting, May 11-12, 2001 Montréal, Quebec Canada).
  2. Kneller J, Shi H, Derakhchan K, Wang Z, Leon LJ, Nattel S. A quantitative analysis of mechanisms of atrial arrhythmias resulting from vagal tone in a mathematical model of dog atrium. Ann Biomed Eng. 2000;28:S55.
  3. Kneller J, Shi H, Derakhchan K, Wang Z, Leon LJ, Nattel S. A quantitative analysis of mechanisms of atrial arrhythmias resulting from vagal tone in a mathematical model of dog atrium. (Poster session, MITACS AGM June 6-7 2000, Toronto, Canada).
  4. Kneller JR, Wu C, Watkins S, Reed M, Weiss L, Feldman MD. Microfabricated device for arterial wall and atherosclerotic plaque penetration. (Oral presentation, 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society) Final Program and Abstract Book, 10/30–11/2, 1997 Chicago IL USA;8.3.1-e:160.
  5. Kneller JR, Wu C, Watkins S, Reed M, Weiss L, Nadeem A, Feldman MD. Microfabricated device for intravascular delivery. (Poster presentation, The Cleveland Clinic Foundation Restenosis Summit IX, 1997).
  6. Kneller JR, Wu C, Watkins S, Reed M, Weiss L, Feldman MD. Microfabricated device for intravascular delivery. (Oral presentation, First International Conference on Cardiovascular Medicine, Surgery, Science, and Mechanics, Bethesda, Maryland, June 6-9, 1997.

Honors & Awards

Professional: Fellow of the Heart Rhythm Society (FHRS) (2013)

Postgraduate: Finalist, Daniel L. Macken Research Competition,
Division of Cardiology, Columbia University Medical Center (’10)

Doctoral dissertation unanimously appointed to the Dean’s Honor List of the Faculty of Graduate Studies and Research, McGill University (2002)

Graduate: Nominated, Governor General’s Gold Medal (2003)

Finalist, Trainee Abstract Award of the Council on Basic Cardiovascular Sciences, 74th Scientific Sessions of the American Heart Association (AHA) 2001, Anaheim CA

First Prize, Best Oral Presentation of the Young Investigator’s Forum

Young investigator’s Forum, CSCI†/RCPSC‡ Annual Meeting, September 21, 2000 Edmonton, Alberta Canada)

(†Canadian Society for Clinical Investigation; ‡The Royal College of Physicians and Surgeons of Canada)

Second Prize, Student Poster Forum

MITACS† AGM, June 6-7, 2000 Toronto, Canada

(†Mathematics of Information Technology and Complex Systems)

Undergraduate: Magna Cum Laude with Honors in Mechanical Engineering (1995)

Engineer In Training (EIT) certification (1995)

Who’s Who Among American Colleges and Universities (1995)

First Prize, ASME† Technical Paper Presentation (1995)

(†American Society of Mechanical Engineers)

National Dean’s List (all terms)

Memberships

Fellow of the Heart Rhythm Society (FHRS)

Professional Member, American Heart Association (AHA) [member ID 158394116]

Peer Reviewer

Council on Basic Cardiovascular Sciences

Functional Genomics and Translational Biology Working Group

American College of Cardiology (ACC)